HuagongsheHuagongshe Chemistry Print Report · For research reference only
Citric Acid → Formoterol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Citric Acid | HCID 311 | — |
| Reactant | Sodium Chloride | HCID 5234 | — |
| Reactant | Trisodium citrate | HCID 6224 | — |
| Reactant | (E)-but-2-enedioic acid N-[2-hydroxy-5-[1-hydroxy-2-[1-(4-methoxyphenyl)propan-2-ylamino]ethyl]phenyl]formamide dihydrate | HCID 11954385 | — |
| Solvent | Water | HCID 962 | — |
| Product | Formoterol | HCID 3410 | — |
Reaction Steps
To a 5 L stainless steel vessel were added 0.68 g citric acid USP, 1.99 g sodium citrate USP, and 17.5 g sodium chloride USP. Purified water USP (2 L) was added to the stainless steel vessel and the contents were mixed with an overhead stirrer at a speed of 240 rpm for 10 minutes. Formoterol fumarate dihydrate (0.17 g for low dosage strength formulation, 0.34 g for high dosage strength formulation) was added and the solution was stirred at 240 rpm for 90 minutes.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06814953B2 |
| Source dataset | uspto-grants-2004_11 |
| ORD ID | ord-dc457e0745ea43b0b61c4929397116fa |
| Source note | uspto-grants-2004_11 |