3-Fluoroacetophenone → Ethyl 3-(3-fluorophenyl)-3-oxopropanoate

HRID 2414756Notes

Reaction equation

HRID 2414756 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([C:8](=[O:10])[CH3:9])[CH:5]=[CH:6][CH:7]=1.[CH2:11]([O:13][C:14](=[O:30])CC(C1C=CC(C2CCCCC2)=CC=1)=O)[CH3:12]>>[CH2:11]([O:13][C:14](=[O:30])[CH2:9][C:8]([C:4]1[CH:5]=[CH:6][CH:7]=[C:2]([F:1])[CH:3]=1)=[O:10])[CH3:12]

Participants

3

Reactant 2

HCID 99673-FluoroacetophenoneHCID 68884378Ethyl 3-(4-cyclohexylphenyl)-3-oxopropanoate

Product 1

HCID 2063904Ethyl 3-(3-fluorophenyl)-3-oxopropanoateYield 91%

Procedure

This compound was prepared from m-fluoro acetophenone, in a manner analogous to the preparation of 3-(4cyclohexylphenyl)-3-oxo-propionic acid ethyl ester (Method A), except that the product was purified by vacuum distillation (bp 114-117° C. at 0.8-0.9 mmHg) in 91% yield.

Workup

  1. distillationwas purified by vacuum distillation (bp 114-117° C. at 0.8-0.9 mmHg) in 91% yield

Sources & evidence

ORD record
ord-6143098e5d3f484ab2aebded6892def1
Source dataset
uspto-grants-2004_11
Patent number
US06815447B2

Reaction notes

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