反应详情

6-Nitro-4-azido-2-(3-fluorophenyl)-quinoline was placed in a 500 mL three neck flask equipped with a condenser, magnetic stirrer, nitrogen inlet gas outlet and a silicone oil heating bath and suspended in 250 mL of ethyl acetate and 50 mL of ethanol. The mixture was stirred, heated to reflux, 20 g (89 mmoles, 6 equiv.) of stannous chloride dihydrate cautiously added portionwise over 40 min, and the mixture was heated for an additional 2 hr. At the end of this time, the mixture was cooled and poured into 500 mL of water. The pH was cautiously adjusted to 9.0 and the solution filtered. Solids were washed with 100 mL of ethyl acetate, the filtrates combined and the aqueous layer twice extracted with 200 mL of ethyl acetate. The organic layers were combined dried over Na2SO4, filtered and concentrated. The product was chromatographed on a silica gel column, using 10% methanol in ethyl acetate as eluent, and was then recrystallized from methylene chloride and hexane to give 3.6 g (88%) of the title compound.

1. customequipped with a condenser, magnetic stirrer, nitrogen inlet gas outlet and a silicone oil heating bath
2. temperatureheated
3. temperatureto reflux
4. temperaturethe mixture was heated for an additional 2 hr
5. temperatureAt the end of this time, the mixture was cooled
6. filtrationthe solution filtered
7. washSolids were washed with 100 mL of ethyl acetate
8. extractionthe aqueous layer twice extracted with 200 mL of ethyl acetate
9. dry with materialThe organic layers were combined dried over Na2SO4
10. filtrationfiltered
11. concentrationconcentrated
12. customThe product was chromatographed on a silica gel column
13. customwas then recrystallized from methylene chloride and hexane