1,1-Dimethylethyl 3-(2-methyl-3-nitrophenoxy)-1-pyrrolidinecarboxylate → HCID 22643441, compound

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Reaction Steps

A mixture of t-butyl 3-(2-methyl-3-nitrophenoxy)pyrrolidin-1-Carboxylate (11.0 g, 34.2 mmol) and 10% Pd/C (0.55 g) in ethanol is hydrogenated (45 psi) at room temperature overnight. After filtering off the catalyst, the filtrate is concentrated to afford the title compound as an off-white solid, 9.98 g, mp 137° C., identified by NMR and mass spectral analyses.

Provenance & Evidence