Ethanol → HCID 22643414, compound

HRID 2414779Notes

Reaction equation

HRID 2414779 reaction equation
[SH:1][C:2]1[NH:3][C:4]2[CH:10]=[CH:9][CH:8]=[CH:7][C:5]=2[N:6]=1.Br[CH2:12][CH2:13][CH2:14][CH2:15][C:16]([OH:18])=[O:17].[OH-].[Na+].[CH2:21](O)[CH3:22]>>[N:3]1[C:4]2[CH:10]=[CH:9][CH:8]=[CH:7][C:5]=2[NH:6][C:2]=1[S:1][CH:13]([CH3:12])[CH2:14][CH2:15][C:16]([O:18][CH2:21][CH3:22])=[O:17]

Participants

5

Reactant 4

HCID 702EthanolHCID 14798Sodium HydroxideHCID 163685-Bromovaleric acidHCID 178527775HCID 178527775, compound

Product 1

HCID 22643414HCID 22643414, compoundYield 83%

Procedure

11 g of 2-mercaptobenzimidazole and 14.6 g of 5-bromovaleric acid were dissolved in 50 ml of ethanol and the mixture was refluxed under heating for 24 hours. After cooling, the mixture was added with wafer and adjusted to pH 8 with aqueous sodium hydroxide. The deposited crystals were collected by filtration and washed with water-containing methanol to obtain 16.9 g of the title compound (yield: 83%).

Workup

  1. temperaturethe mixture was refluxed
  2. temperatureunder heating for 24 hours
  3. temperatureAfter cooling
  4. additionthe mixture was added with wafer
  5. filtrationThe deposited crystals were collected by filtration
  6. washwashed with water-
  7. additioncontaining methanol

Sources & evidence

ORD record
ord-1d1db9b519a84713985596ed8bde10c2
Source dataset
uspto-grants-2004_11
Patent number
US06815455B1

Reaction notes

Loading…