Hydrochloric Acid → HCID 69764691, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 7-cyano-1-(3,4-dichloro-benzyl)-6-methoxy-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester (3.60 g, 8.06 mmol) in benzyl alcohol (10 mL) is added KOH (3.00 g), and the reaction mixture is stirred at 160° C. for 0.5 h. The reaction mixture is allowed to cool to rt and is acidified with 2 M aqueous HCl. The reaction mixture is partitioned with EtOAc (3×20 mL). The combined organic phases are washed with brine, dried over MgSO4, filtered, and evaporated to yield a yellow oil. Chromatography over silica gel with CH2Cl2:MeOH 19:1 and then with MeOH provides the title compound as yellow solid.

Provenance & Evidence