4,4,4-Trifluorobutanal → (5R)-5-ethyl-9-fluoro-5-hydroxy-12-(3,3,3-trifluoropropyl)-4,5,13,15-tetrahydro-1H,3H-oxepino[3',4':6,7]indolizino [1,2-b]quinoline-3,15-dione

Participants

Role	Name	HCID	Charge
Reactant	4,4,4-Trifluorobutanal	HCID 2777083	—
Reactant	(5R)-5-ethyl-9-fluoro-5-hydroxy-4,5,13,15-tetrahydro-1H,3H-oxepino[3',4':6,7]indolizino[1,2-b]quinoline-3,15-dione	HCID 9929755	—
Product	(5R)-5-ethyl-9-fluoro-5-hydroxy-12-(3,3,3-trifluoropropyl)-4,5,13,15-tetrahydro-1H,3H-oxepino[3',4':6,7]indolizino [1,2-b]quinoline-3,15-dione	HCID 69591349	—

Reaction Steps

The product of Example 84 is treated with 4,4,4-trifluorobutyraldehyde according to a procedure similar to Stage 95e in order to produce the expected solid.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US06815546B2
Source dataset	uspto-grants-2004_11
ORD ID	ord-c59267051d30416bbbc907ab44dc735f
Source note	uspto-grants-2004_11