Ethyl trifluoroacetate → HCID 20598898, compound

HRID 2415005Notes

Reaction equation

HRID 2415005 reaction equation
[CH2:1]([O:8][C:9](=[O:17])[CH2:10][CH2:11][C@@H:12]([C:14]([OH:16])=[O:15])[NH2:13])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C([O:20][C:21](=O)[C:22]([F:25])([F:24])[F:23])C>C(O)C>[CH2:1]([O:8][C:9](=[O:17])[CH2:10][CH2:11][C@@H:12]([C:14]([OH:16])=[O:15])[NH:13][C:21](=[O:20])[C:22]([F:25])([F:24])[F:23])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 9794Ethyl trifluoroacetateHCID 122337L-Glutamic acid, 5-(phenylmethyl) ester

Product 1

HCID 20598898HCID 20598898, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

100 g (421.5 mmol) of L-glutamic acid-5-benzylester is dissolved in a mixture that consists of 1000 ml of trifluoroacetic acid ethyl ester/500 ml of ethanol, and it is stirred for 24 hours at room temperature. It is evaporated to the dry state, and the residue is crystallized from diisopropyl ether.

Workup

  1. customIt is evaporated to the dry state
  2. customthe residue is crystallized from diisopropyl ether

Sources & evidence

ORD record
ord-b7052e22a14d49289a2c599dd65d4497
Source dataset
uspto-grants-2004_11
Patent number
US06818203B2

Reaction notes

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