Imidazole → HCID 12151211, compound

HRID 2415032Notes

Reaction equation

HRID 2415032 reaction equation
Cl[C:2]1[C:7]([I:8])=[C:6]([C:9]([F:12])([F:11])[F:10])[N:5]=[C:4]([S:13][CH:14]([CH3:16])[CH3:15])[N:3]=1.[NH:17]1[CH:21]=[CH:20][N:19]=[CH:18]1>C(#N)C>[N:17]1([C:2]2[C:7]([I:8])=[C:6]([C:9]([F:12])([F:11])[F:10])[N:5]=[C:4]([S:13][CH:14]([CH3:16])[CH3:15])[N:3]=2)[CH:21]=[CH:20][N:19]=[CH:18]1

Participants

4

Reactant 2

HCID 795ImidazoleHCID 12151420HCID 12151420, compound

Product 1

HCID 12151211HCID 12151211, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

4-Chloro-5-iodo-2-isopropylthio-6-trifluoromethylpyrimidine (3.0 g) was dissolved in acetonitrile (30 ml) and imidazole (1.6 g) was added at room temperature with stirring. The mixture was refluxed fbr 3 hr and then the solvent was removed under reduced pressure. The residue was added water and precipitates was filtered off to give crude 4-imidazol-1-yl-5-iodo-2-isopropylthio-6-trifluoromethyl-pyrimidine. It was recryslized from methanol-water mixture as colorless needles (2.61 g), mp 118-120° C.

Workup

  1. temperatureThe mixture was refluxed fbr 3 hr
  2. customthe solvent was removed under reduced pressure
  3. additionThe residue was added water
  4. customprecipitates
  5. filtrationwas filtered off

Sources & evidence

ORD record
ord-fbcaca7eab19404b82671bc3e99371b9
Source dataset
uspto-grants-2004_11
Patent number
US06818631B1

Reaction notes

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