Dimethylamine → HCID 178482967, compound

HRID 2415040Notes

Reaction equation

HRID 2415040 reaction equation
O.[NH2:2][C:3]1[N:8]=[C:7](Cl)[CH:6]=[C:5]([OH:10])[N:4]=1.[CH3:11][NH:12][CH3:13]>C(O)C>[NH2:2][C:3]1[N:8]=[C:7]([N:12]([CH3:13])[CH3:11])[CH:6]=[C:5]([OH:10])[N:4]=1

Participants

4

Reactant 2

HCID 674DimethylamineHCID 178508975HCID 178508975, compound

Product 1

HCID 178482967HCID 178482967, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

2-Amino-4-chloro-6-hydroxypyrimidine monohydrate (5.0 g) was stirred with 30% dimethylamine in ethanol (180 mL) at 100° C. in an autoclave for 16 h. The crystalline product was filtered, washed with water, acetone, ether and dried in vacuo to afford 2-amino-4-dimethylamino-6-hydroxypyrimidine, not melting under 300° C. Yield, 4.3 g (81%). For C6H10N4O (154.17) calculated 46.34% C, 6.54% H, 36.34% N; found 46.38% C, 6.65% H, 36.68% N. 1H-NMR (CD3SOCD3): 2.89 s, 6H (N—CH3); 4.51 s, 1H (H-5); 6.18 brs, 2H (NH2); 9.75 brs, 1H (OH).

Workup

  1. filtrationThe crystalline product was filtered
  2. washwashed with water, acetone, ether
  3. customdried in vacuo

Sources & evidence

ORD record
ord-630ad0f4650a45cba01a529d8d0727b5
Source dataset
uspto-grants-2004_11
Patent number
US06818633B2

Reaction notes

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