Water → HCID 22640035, compound

Participants

Reaction Conditions

Reaction Steps

0.18 g (3.6 mmol) of 6-chloro-3-nitro-imidazo[1,2-b]pyridazine are added to a solution of 0.85 g (3.6 mmol) of 4-[(5-chloro-pyrimidin-4-ylamino)-methyl]-phenol (from example A14) and 2.5 g (18 mmol) of potassium carbonate in 10 ml of dry N,N-dimethylformamide and the reaction mixture is stirred at 80° C. for 3 h. The temperature is allowed to raise to room temperature and the mixture is poured into water (100 ml). The precipitate is filtered off and purified by silica gel chromatography (toluene/dioxane=2:1) to yield 1.1 g (78%) of the title compound as a beige powder of m.p. 185° C.

Provenance & Evidence