Hydrochloric Acid → 4-[(5-Chloro-2,6-dimethylpyrimidin-4-ylamino)methyl]-2-methoxyphenol

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Reaction Steps

In analogy to the method described in example B1, 3.0 g (7.8 mmol) of (4-benzyloxy-3-methoxy-benzyl)(5-chloro-2,6-dimethylpyrimidin-4-yl)amine (from example A3) are reacted with 30 ml of 12.5N hydrochloric acid in 30 ml of ethanol. Extraction with ethyl acetate at a pH of 8 gives, after concentration, a solid residue which is chromatographed on silica gel (mobile phase: toluene/dioxane=5:1). Crystallization with toluene gives 1.38 g (60%) of the title compound as a beige crystallizate. m.p.: 179-181.5° C.

Provenance & Evidence