HCID 6918654, compound → HCID 22640505, compound

Participants

Reaction Steps

500 mg of 1-[4-(4-Trifluoromethoxybenzenesulfonamido)-3-methoxyphenyl]-7-chloro-3,4-dihydroisoquinoline (1a) are dissolved in 500 μl of of dimethylformamide. To this solution 560 mg of potassium tert.-butylate in 4000 μl of dimethylformamide are added under an atmosphere of oxygen. The reaction mixture is stirred at RT for 4 h and evaporated to dryness. The residue is dissolved in ethyl acetate/water and the organic layer is separated. The aqueous layer is extracted twice with ethyl acetate and the combined organic layers are dried and evaporated. The product is stirred out of diethylether to yield 215 mg of the title compound.

Provenance & Evidence