Ammonium formate → HCID 22640493, compound

Participants

Reaction Steps

3 g of 1-(3-methoxy4-nitrophenyl)-7chloro-3,4-dihydroisoquinoline (starting compound B1) are suspended in methanol, and 2.4 g of ammonium formate and 60 mg of palladium on charcoal (10%) are added to this suspension. The reaction mixture is stirred at RT for 5 h, filtered through Celite and concentrated. The residue is purified by flash chromatography on silica gel. It is stirred out of diethyl ether/n-hexane, filtered with suction and dried. 2.4 g of the title compound are obtained.

Provenance & Evidence