4-Methoxybiphenyl → HCID 22640158, compound

Participants

Reaction Steps

1.6 ml (0.05 mol) of butyllithium solution in n-hexane is added dropwise to a solution of 8.81 g (0.05 mol) of 1-benzylpiperazine in 50 ml of anhydrous THF under argon at 0° C. and stirred for one hour. Then 9.21 g (0.05 mol) of 4-methoxybiphenyl are added and the reaction mixture is refluxed for 12 hours. The solvent is then evaporated off, the residue is combined with 150 ml of 2 N hydrochloric acid followed by diethyl ether and the precipitate formed is filtered off. The precipitate is washed with diethyl ether, suspended in 20% sodium carbonate solution and extracted several times with dichloromethane. After drying over magnesium sulphate the solvent is removed and the residue is washed with ethyl acetate and diethyl ether.

Provenance & Evidence