HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 241515Generated: October 30, 2026
Ethanol → 4-[4-(3,5-dichloro-phenyl)-4-trifluoromethyl-4,5-dihydro-3H-pyrrol-2-yl]-2-methyl-benzaldehyde-ethylsemicarbazone
https://huagongshe.com/reaction/241515
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ethanol | HCID 702 | — |
| Reactant | Ethyl semicarbazide hydrochloride | HCID 86690409 | — |
| Reactant | 4-[3-(3,5-Dichlorophenyl)-3-(trifluoromethyl)-2,4-dihydropyrrol-5-yl]-2-methyl-benzaldehyde | HCID 86691047 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | 4-[4-(3,5-dichloro-phenyl)-4-trifluoromethyl-4,5-dihydro-3H-pyrrol-2-yl]-2-methyl-benzaldehyde-ethylsemicarbazone | HCID 66836738 | 60% |
Reaction Steps
A mixture of 4-[4-(3,5-dichloro-phenyl)-4-trifluoromethyl-4,5-dihydro-3H-pyrrol-2-yl]-2-methyl-benzaldehyde (208 mg, 0.520 mmol) and ethyl semicarbazide hydrochloride (109 mg 0.780 mmol) in ethanol (5 mL) and glacial acetic acid (0.1 mL) was heated at 70° C. for 4 h. After cooling, the mixture was concentrated in vacuum. The residue was purified by flash chromatography on silica gel to give the title compound (151 mg, 60%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08653000B2 |
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| Source dataset | uspto-grants-2014_02 |
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| ORD ID | ord-322d62e1edea4388a836c312a79de4a0 |
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| Source note | uspto-grants-2014_02 |
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