HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 241516Generated: October 30, 2026
Ethanol → 4-[4-(3,5-dichloro-phenyl)-4-trifluoromethyl-4,5-dihydro-3H-pyrrol-2-yl]-2-methyl-benzaldehyde-ethylthiosemicarbazone
https://huagongshe.com/reaction/241516
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ethanol | HCID 702 | — |
| Reactant | 2-Ethylhydrazinecarbothioamide | HCID 22105028 | — |
| Reactant | 4-[3-(3,5-Dichlorophenyl)-3-(trifluoromethyl)-2,4-dihydropyrrol-5-yl]-2-methyl-benzaldehyde | HCID 86691047 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | 4-[4-(3,5-dichloro-phenyl)-4-trifluoromethyl-4,5-dihydro-3H-pyrrol-2-yl]-2-methyl-benzaldehyde-ethylthiosemicarbazone | HCID 123574342 | 76% |
Reaction Steps
A mixture of 4-[4-(3,5-dichloro-phenyl)-4-trifluoromethyl-4,5-dihydro-3H-pyrrol-2-yl]-2-methyl-benzaldehyde (208 mg, 0.520 mmol) and ethyl thiosemicarbazide (93 mg 0.12 mmol) in ethanol (5 mL) and glacial acetic acid (0.1 mL) was heated at 70° C. for 4 h. After cooling, the resulting precipitate was filtered and dried to give the title compound (198 mg, 76%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08653000B2 |
|---|
| Source dataset | uspto-grants-2014_02 |
|---|
| ORD ID | ord-06711fce0d6a45e9b983e9ef9313462c |
|---|
| Source note | uspto-grants-2014_02 |
|---|
