1-(6-Methoxypyridin-2-yl)piperazine → 9-{4-[4-(6-methoxy-pyridin-2-yl)-piperazin-1-yl]-butyl}-9H-fluorene-9-carboxylic acid-4-fluorobenzyl-amide

HRID 2415160Notes

Reaction equation

HRID 2415160 reaction equation
[CH3:1][O:2][C:3]1[N:8]=[C:7]([N:9]2[CH2:14][CH2:13][NH:12][CH2:11][CH2:10]2)[CH:6]=[CH:5][CH:4]=1.[F:15][C:16]1[CH:43]=[CH:42][C:19]([CH2:20][NH:21][C:22]([C:24]2([CH2:37][CH2:38][CH2:39][CH2:40]Br)[C:36]3[CH:35]=[CH:34][CH:33]=[CH:32][C:31]=3[C:30]3[C:25]2=[CH:26][CH:27]=[CH:28][CH:29]=3)=[O:23])=[CH:18][CH:17]=1>>[F:15][C:16]1[CH:17]=[CH:18][C:19]([CH2:20][NH:21][C:22]([C:24]2([CH2:37][CH2:38][CH2:39][CH2:40][N:12]3[CH2:13][CH2:14][N:9]([C:7]4[CH:6]=[CH:5][CH:4]=[C:3]([O:2][CH3:1])[N:8]=4)[CH2:10][CH2:11]3)[C:36]3[CH:35]=[CH:34][CH:33]=[CH:32][C:31]=3[C:30]3[C:25]2=[CH:26][CH:27]=[CH:28][CH:29]=3)=[O:23])=[CH:42][CH:43]=1

Participants

3

Reactant 2

HCID 122004701-(6-Methoxypyridin-2-yl)piperazineHCID 226362389-(4-bromo-butyl)-9H-fluorene-9-carboxylic acid-4-fluoro-benzylamide

Product 1

HCID 226401259-{4-[4-(6-methoxy-pyridin-2-yl)-piperazin-1-yl]-butyl}-9H-fluorene-9-carboxylic acid-4-fluorobenzyl-amide

Procedure

Prepared analogously to Example 2 b from 1-(6-methoxy-pyridin-2-yl)-piperazine and 9-(4-bromo-butyl)-9H-fluorene-9-carboxylic acid-4-fluorobenzyl-amide.

Sources & evidence

ORD record
ord-b20bd951dcf94555bdf93a3de6206105
Source dataset
uspto-grants-2004_11
Patent number
US06818644B1

Reaction notes

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