HRID2415165

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID667618

1-[5-(Trifluoromethyl)pyridin-2-yl]piperazine

C10H12F3N3

结构：O=C(NCC(F)(F)F)C1(CCCCBr)c2ccccc2-c2ccccc21

HCID10526437

9-(4-Bromobutyl)-N-(2,2,2-trifluoroethyl)-9H-fluorene-9-carboxamide

C20H19BrF3NO

PRODUCTS

生成物

结构：O=C(NCC(F)(F)F)C1(CCCCN2CCN(c3ccc(C(F)(F)F)cn3)CC2)c2ccccc2-c2ccccc21

HCID22640124

未命名化合物

PROCEDURE

实验过程

Prepared analogously to Example 2 b from 1-(5-trifluoromethyl-pyridin-2-yl)-piperazine and 9-(4-bromo-butyl)-9H-fluorene-9-carboxylic acid-(2,2,2-trifluoroethyl)-amide.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-a6adc79e1ed7411290bdd4532c069faa
来源数据集: uspto-grants-2004_11
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06818644B1
来源说明: uspto-grants-2004_11

反应 SMILES

[F:1][C:2]([F:16])([F:15])[C:3]1[CH:4]=[CH:5][C:6]([N:9]2[CH2:14][CH2:13][NH:12][CH2:11][CH2:10]2)=[N:7][CH:8]=1.[F:17][C:18]([F:42])([F:41])[CH2:19][NH:20][C:21]([C:23]1([CH2:36][CH2:37][CH2:38][CH2:39]Br)[C:35]2[CH:34]=[CH:33][CH:32]=[CH:31][C:30]=2[C:29]2[C:24]1=[CH:25][CH:26]=[CH:27][CH:28]=2)=[O:22]>>[F:17][C:18]([F:41])([F:42])[CH2:19][NH:20][C:21]([C:23]1([CH2:36][CH2:37][CH2:38][CH2:39][N:12]2[CH2:11][CH2:10][N:9]([C:6]3[CH:5]=[CH:4][C:3]([C:2]([F:1])([F:15])[F:16])=[CH:8][N:7]=3)[CH2:14][CH2:13]2)[C:35]2[CH:34]=[CH:33][CH:32]=[CH:31][C:30]=2[C:29]2[C:24]1=[CH:25][CH:26]=[CH:27][CH:28]=2)=[O:22]