9-(4-bromo-butyl)-9H-fluorene-9-carboxylic acid-4-fluoro-benzylamide → HCID 22640118, compound

HRID 2415178Notes

Reaction equation

HRID 2415178 reaction equation
[CH3:1][O:2][C:3]1[N:8]=[C:7]([N:9]2[CH2:14][CH:13]([CH3:15])[NH:12][CH:11]([CH3:16])[CH2:10]2)[CH:6]=[CH:5][CH:4]=1.[F:17][C:18]1[CH:45]=[CH:44][C:21]([CH2:22][NH:23][C:24]([C:26]2([CH2:39][CH2:40][CH2:41][CH2:42]Br)[C:38]3[CH:37]=[CH:36][CH:35]=[CH:34][C:33]=3[C:32]3[C:27]2=[CH:28][CH:29]=[CH:30][CH:31]=3)=[O:25])=[CH:20][CH:19]=1>>[F:17][C:18]1[CH:19]=[CH:20][C:21]([CH2:22][NH:23][C:24]([C:26]2([CH2:39][CH2:40][CH2:41][CH2:42][N:12]3[CH:11]([CH3:16])[CH2:10][N:9]([C:7]4[CH:6]=[CH:5][CH:4]=[C:3]([O:2][CH3:1])[N:8]=4)[CH2:14][CH:13]3[CH3:15])[C:38]3[CH:37]=[CH:36][CH:35]=[CH:34][C:33]=3[C:32]3[C:27]2=[CH:28][CH:29]=[CH:30][CH:31]=3)=[O:25])=[CH:44][CH:45]=1

Participants

3

Reactant 2

HCID 226362389-(4-bromo-butyl)-9H-fluorene-9-carboxylic acid-4-fluoro-benzylamideHCID 22640152HCID 22640152, compound

Product 1

HCID 22640118HCID 22640118, compound

Procedure

Prepared analogously to Example 2 b from 1-(6-methoxy-pyridin-2-yl)-3,5-dimethyl-piperazine and 9-(4-bromo-butyl)-9H-fluorene-9-carboxylic acid-4-fluorobenzyl-amide.

Sources & evidence

ORD record
ord-9028b5d1130f4c8bb5b8554051a05125
Source dataset
uspto-grants-2004_11
Patent number
US06818644B1

Reaction notes

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