Cyanamide → HCID 60063784, compound

Participants

Reaction Steps

Cyanamide (46.2 mg, 1.1 mmol) was suspended in acetonitrile (5 mL). To the stirred suspension, potassium tert-butoxide (123 mg, 1.1 mmol) in 2 mL of tert-butanol was added followed by isothiocyanate (Example 1, 334 mg, 1 mmol). The mixture was stirred for 30 minutes at room temperature followed by the addition of 2-bromo-1-(3-fluoro-phenyl)-ethanone (TCI, 261 mg, 1 mmol). After being stirred for 2 hours at room temperature, the mixture was poured into water and the new mixture was extracted with ether. The extract was dried(Na2SO4) and concentrated to give the desired product as a yellow solid, 510 mg, 99%. MS (ES) MH+=513.

Provenance & Evidence