HCID 60063784, compound → HCID 10070268, compound

Participants

Reaction Steps

(S)-2-[4-[4-Amino-5-(3fluoro-benzoyl)-thiazol-2-ylamino]-phenoxymethyl]-pyrrolidine-1-carboxylic acid tert-butyl ester (Example 2, 200 mg, 0.39 mmol) was suspended in 1N HCl in diethyl ether and the mixture was stirred at room temperature overnight. The solid was filtered and passed through a C18 column eluting with aqueous ammonia in acetonitrile. The mixture was concentrated and the solid was filtered and dried to give a yellow solid. 120 mg, 75%. MS (ES) MH+=413.

Provenance & Evidence