反应详情

To a stirred solution of 1-(3-ethyl-4-fluoro-phenyl)-ethanone (400 mg, 2.41 mmol) (from Step D) in 1,4-dioxane, bromine (124 μL, 2.41 mmol) was added and the mixture was stirred for 30 minute. at room temperature. The solvent was removed and the residue was chromatographed (5% dichloromethane/hexanes) to give an oil. 317 mg, 54%. 1H NMR(CDCl3, 300 MHz), σ 1.2-1.35 (t, 3H), 2.67-2.80 (q, 2H), 4.42 (s, 2H), 7.03-7.0 (t, 1H), 4.45 (s, 2H), 7.75-7.92 (m, 2H).

1. customat room temperature
2. customThe solvent was removed
3. customthe residue was chromatographed (5% dichloromethane/hexanes)
4. customto give an oil