Cyanamide → HCID 23525769, compound

Participants

Reaction Steps

Cyanamide (46.2 mg, 1.1 mmol) was suspended in acetonitrile (5 mL). To the stirred suspension, potassium tert-butoxide (123 mg, 1.1 mmol) in 2 mL of tert-butanol was added followed by isothiocyanate (Example 19, 306 mg, 1 mmol). The mixture was stirred for 30 minutes at room temperature followed by the addition of 2-bromo-1-(3-fluoro-phenyl)-ethanone (TCl, 216 mg, 1 mmol). After being stirred for 2 hours at room temperature, the mixture was poured into water and the new mixture was extracted with ether. The extract was dried (Na2SO4) and concentrated to give the desired product as a yellow solid, 480 mg, 99%. MS (ES) MH+=485.

Provenance & Evidence