Cyanamide → HCID 10413717, compound

HRID 2415270Notes

Reaction equation

HRID 2415270 reaction equation
[N:1]#[C:2][NH2:3].[N:4]([C:7]1[CH:20]=[CH:19][C:10]([O:11][CH2:12][CH2:13][N:14]2[CH2:18][CH2:17][CH2:16][CH2:15]2)=[CH:9][CH:8]=1)=[C:5]=[S:6].Br[CH2:22][C:23]([C:25]1[CH:30]=[CH:29][C:28]([OH:31])=[C:27]([F:32])[CH:26]=1)=[O:24]>>[C:10]([OH:24])(=[O:11])[CH3:19].[NH2:1][C:2]1[N:3]=[C:5]([NH:4][C:7]2[CH:8]=[CH:9][C:10]([O:11][CH2:12][CH2:13][N:14]3[CH2:15][CH2:16][CH2:17][CH2:18]3)=[CH:19][CH:20]=2)[S:6][C:22]=1[C:23]([C:25]1[CH:30]=[CH:29][C:28]([OH:31])=[C:27]([F:32])[CH:26]=1)=[O:24]

Participants

4

Reactant 3

HCID 9864CyanamideHCID 118461221-(2-(4-Isothiocyanatophenoxy)ethyl)pyrrolidineHCID 179235302-Bromo-1-(3-fluoro-4-hydroxyphenyl)ethan-1-one

Product 1

HCID 10413717HCID 10413717, compound

Procedure

This compound was prepared from cyanamide and 1-[2-(4-isothiocyanato-phenoxy)-ethyl]-pyrrolidine (from Example 5) and 2-bromo-1-(3-fluoro-4-hydroxyphenyl)-ethanone (from Example 119) following the procedure used in Example 118. Mass spectrum (ES) MH+=453.

Sources & evidence

ORD record
ord-55e26bd0ef0d401f87c8b67a4a3160aa
Source dataset
uspto-grants-2004_11
Patent number
US06818663B2

Reaction notes

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