Cyanamide → HCID 86590644, compound

HRID 2415271Notes

Reaction equation

HRID 2415271 reaction equation
[N:1]#[C:2][NH2:3].[N:4]([C:7]1[CH:21]=[CH:20][C:10]([O:11][CH2:12][C@H:13]([N:15]2[CH2:19][CH2:18][CH2:17][CH2:16]2)[CH3:14])=[CH:9][CH:8]=1)=[C:5]=[S:6].Br[CH2:23][C:24]([C:26]1[CH:31]=[CH:30][CH:29]=[C:28]([O:32][CH3:33])[CH:27]=1)=[O:25]>>[C:10]([OH:25])(=[O:11])[CH3:20].[NH2:1][C:2]1[N:3]=[C:5]([NH:4][C:7]2[CH:8]=[CH:9][C:10]([O:11][CH2:12][C@H:13]([N:15]3[CH2:16][CH2:17][CH2:18][CH2:19]3)[CH3:14])=[CH:20][CH:21]=2)[S:6][C:23]=1[C:24]([C:26]1[CH:31]=[CH:30][CH:29]=[C:28]([O:32][CH3:33])[CH:27]=1)=[O:25]

Participants

4

Reactant 3

HCID 9864CyanamideHCID 101294Bromomethyl 3-methoxyphenyl ketoneHCID 60063780HCID 60063780, compound

Product 1

HCID 86590644HCID 86590644, compound

Procedure

This compound was prepared from cyanamide, [R]-1-[2-(4-isothiocyanato-phenoxy)-1-methyl-ethyl)-pyrrolidine (of Example 11) and 2-bromo-1-(3-methoxyphenyl)ethanone (Aldrich) following the procedure used in Example 118. Mass spectrum (ES) MH+=453.

Sources & evidence

ORD record
ord-93302a543f1a48d291dafd8c275b45e6
Source dataset
uspto-grants-2004_11
Patent number
US06818663B2

Reaction notes

Loading…