Cyanamide → HCID 10027956, compound

HRID 2415276Notes

Reaction equation

HRID 2415276 reaction equation
N#CN.C(O)(=O)C.[NH2:8][C:9]1[N:10]=[C:11]([NH:23][C:24]2[CH:29]=[CH:28][C:27]([O:30][CH2:31][CH2:32][N:33]3[CH2:37][CH2:36][CH2:35][CH2:34]3)=[CH:26][CH:25]=2)[S:12][C:13]=1[C:14]([C:16]1[CH:21]=[CH:20][CH:19]=[C:18](F)[CH:17]=1)=[O:15].BrCC(C1C=CC=C([C:48]([F:51])([F:50])[F:49])C=1)=O>>[NH2:8][C:9]1[N:10]=[C:11]([NH:23][C:24]2[CH:29]=[CH:28][C:27]([O:30][CH2:31][CH2:32][N:33]3[CH2:34][CH2:35][CH2:36][CH2:37]3)=[CH:26][CH:25]=2)[S:12][C:13]=1[C:14]([C:16]1[CH:21]=[CH:20][CH:19]=[C:18]([C:48]([F:51])([F:50])[F:49])[CH:17]=1)=[O:15]

Participants

4

Reactant 3

HCID 9864CyanamideHCID 27783862-Bromo-1-[3-(trifluoromethyl)phenyl]ethan-1-oneHCID 10323136HCID 10323136, compound

Product 1

HCID 10027956HCID 10027956, compound

Procedure

This compound was prepared from cyanamide, 1-[2-(isothiocyanato-phenoxy)-ethyl]-pyrrolidine of Example 118 and 2-bromo-1-(3-trifluoromethyl-phenyl)-ethanone of Example 127 following a procedure similar to Example 123. Mass spectrum (ES) MH+=477.

Sources & evidence

ORD record
ord-213779246b904aab831758ac06bc130e
Source dataset
uspto-grants-2004_11
Patent number
US06818663B2

Reaction notes

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