Ethyl-[2-(4-nitro-phenoxy)-ethyl]-carbamic acid tert-butyl ester → [2-(4-Amino-phenoxy)-ethyl]-ethyl-carbamic acid tert-butyl ester

Participants

Reaction Steps

A solution of ethyl-[2-(4-nitro-phenoxy)-ethyl]-carbamic acid tert-butyl ester (825 mg, 2.36 mmol) (from step B above) and 150 mg of 10% palladium-on-carbon in ethanol (25 mL) was hydrogenated at 20 psi in a Parr shaker for 1 hour. The mixture was filtered through Celite™ and the solvent was evaporated to give 750 mg (100%) [2-(4-amino-phenoxy)-ethyl]-ethyl-carbamic acid tert-butyl ester.

Provenance & Evidence