HRID241528

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CCCCc1nc(Cl)c(CO)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1

HCID3961

Losartan

C22H23ClN6O

结构：CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)O

HCID123805

未命名化合物

2 次

HCID178418600

未命名化合物

3 次

PRODUCTS

生成物

结构：CCCCc1nc(Cl)c(CO)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1.CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)O.N=C(N)NCCC[C@H](N)C(=O)O

HCID178441682

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID962

Water

H2O

2 次

PROCEDURE

实验过程

The Ang-(1-7) losartanate compound (PID) was weighed and placed in a beaker to which a few milliliters of Milli-Q water were added. Since this compound is insoluble in water a turbid solution was observed having suspended particles. L-arginine was added to the solution under agitation, at a molar ratio of 4:1:1 (L-arginine:Losartan:Angiotensin-(1-7)), and a total clearing of the solution was observed, which indicated the solubility of the compound after the interaction with L-arginine. The final solution was placed in eppendorf tubes and frozen in liquid nitrogen, being submitted to the lyophilization process for 24 hours. The compound was called PAD and was submitted to physicochemical characterization.

WORKUP

后处理

additionwere added
temperaturefrozen in liquid nitrogen

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-75fe930b28d34ffb8011e18951ae6050
来源数据集: uspto-grants-2014_02
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08653031B2
来源说明: uspto-grants-2014_02

反应 SMILES

[CH3:1][CH2:2][C@@H:3]([C@H:5]([NH:26][C:27]([C@@H:29]([NH:38][C:39]([C@@H:41]([NH:45][C:46]([C@@H:48]([NH:56][C:57]([C@@H:59]([NH2:64])[CH2:60][C:61]([OH:63])=[O:62])=[O:58])[CH2:49][CH2:50][CH2:51][N:52]=[C:53]([NH2:55])[NH2:54])=[O:47])[CH:42]([CH3:44])[CH3:43])=[O:40])[CH2:30][C:31]1[CH:36]=[CH:35][C:34]([OH:37])=[CH:33][CH:32]=1)=[O:28])[C:6]([NH:8][C@H:9]([C:16]([N:18]1[C@H:22]([C:23]([OH:25])=[O:24])[CH2:21][CH2:20][CH2:19]1)=[O:17])[CH2:10][C:11]1[NH:15][CH:14]=[N:13][CH:12]=1)=[O:7])[CH3:4].[NH2:65][C@H:66]([C:74]([OH:76])=[O:75])[CH2:67][CH2:68][CH2:69][NH:70][C:71](=[NH:73])[NH2:72].[CH3:77][CH2:78][CH2:79][CH2:80][C:81]1[N:85]([CH2:86][C:87]2[CH:88]=[CH:89][C:90]([C:93]3[CH:94]=[CH:95][CH:96]=[CH:97][C:98]=3[C:99]3[N:103]=[N:102][NH:101][N:100]=3)=[CH:91][CH:92]=2)[C:84]([CH2:104][OH:105])=[C:83]([Cl:106])[N:82]=1>O>[CH3:77][CH2:78][CH2:79][CH2:80][C:81]1[N:85]([CH2:86][C:87]2[CH:92]=[CH:91][C:90]([C:93]3[CH:94]=[CH:95][CH:96]=[CH:97][C:98]=3[C:99]3[N:103]=[N:102][NH:101][N:100]=3)=[CH:89][CH:88]=2)[C:84]([CH2:104][OH:105])=[C:83]([Cl:106])[N:82]=1.[CH3:1][CH2:2][C@@H:3]([C@H:5]([NH:26][C:27]([C@@H:29]([NH:38][C:39]([C@@H:41]([NH:45][C:46]([C@@H:48]([NH:56][C:57]([C@@H:59]([NH2:64])[CH2:60][C:61]([OH:63])=[O:62])=[O:58])[CH2:49][CH2:50][CH2:51][N:52]=[C:53]([NH2:55])[NH2:54])=[O:47])[CH:42]([CH3:44])[CH3:43])=[O:40])[CH2:30][C:31]1[CH:32]=[CH:33][C:34]([OH:37])=[CH:35][CH:36]=1)=[O:28])[C:6]([NH:8][C@H:9]([C:16]([N:18]1[C@H:22]([C:23]([OH:25])=[O:24])[CH2:21][CH2:20][CH2:19]1)=[O:17])[CH2:10][C:11]1[NH:15][CH:14]=[N:13][CH:12]=1)=[O:7])[CH3:4].[NH2:65][C@H:66]([C:74]([OH:76])=[O:75])[CH2:67][CH2:68][CH2:69][NH:70][C:71](=[NH:72])[NH2:73]