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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2415281Generated: October 25, 2026

Cyanamide → [4-Amino-2-[4-(2-ethylamino-ethoxy)-phenylamino]-thiazol-5-yl]-(3-fluoro-phenyl)-methanone

https://huagongshe.com/reaction/2415281

Reaction equation

Participants

RoleNameHCIDCharge
ReactantCyanamideHCID 9864—
Reactant3-Fluorophenacyl bromideHCID 2737451—
ReactantEthyl-[2-(4-isothiocyanato-phenoxy)-ethyl]-carbamic acid tert-butyl esterHCID 23525784—
Product[4-Amino-2-[4-(2-ethylamino-ethoxy)-phenylamino]-thiazol-5-yl]-(3-fluoro-phenyl)-methanoneHCID 9978339—

Reaction Steps

This compound was prepared from cyanamide, ethyl-[2-(4-isothiocyanato-phenoxy)-ethyl]-carbamic acid tert-butyl ester of Example 129D and 2-bromo-1-(3-fluorophenyl)ethanone (Maybridge Chemical) following a procedure similar to Example 123. Mass spectrum (ES) MH+=401.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06818663B2
Source datasetuspto-grants-2004_11
ORD IDord-dda1f29d51e348409ee13d2778357026
Source noteuspto-grants-2004_11