Cyanamide → [4-Amino-2-[4-(2-ethylamino-ethoxy)-phenylamino]-thiazol-5-yl]-(2,3-dihydro-benzo[1,4]dioxin-6-yl)-methanone

Participants

Role	Name	HCID	Charge
Reactant	Cyanamide	HCID 9864	—
Reactant	2-Bromo-1-(2,3-dihydro-1,4-benzodioxin-6-yl)ethan-1-one	HCID 2776171	—
Reactant	Ethyl-[2-(4-isothiocyanato-phenoxy)-ethyl]-carbamic acid tert-butyl ester	HCID 23525784	—
Product	[4-Amino-2-[4-(2-ethylamino-ethoxy)-phenylamino]-thiazol-5-yl]-(2,3-dihydro-benzo[1,4]dioxin-6-yl)-methanone	HCID 10094791	—

Reaction Steps

This compound was prepared from cyanamide, ethyl-[2-(4-isothiocyanato-phenoxy)-ethyl]-carbamic acid tert-butyl ester of Example 129D and 2-bromo-1-(2,3-dihydro-benzo[1,4]dioxin-6-yl)ethanone (Maybridge Chemical) following a procedure similar to Example 133. Mass spectrum (ES) MH+=441.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US06818663B2
Source dataset	uspto-grants-2004_11
ORD ID	ord-fbec466665b54d02b50e949eab13324d
Source note	uspto-grants-2004_11