1,1'-Thiocarbonyldiimidazole → HCID 86590645, compound

Participants

Reaction Conditions

Reaction Steps

Thiocarbonyldiimidazole (3.64 g, 20.44 mmol) (Aldrich) was dissolved in N,N-dimethylformamide (3 mL) and the solution was cooled to −15° C. A solution [2-(4-amino-phenoxy)-ethyl]-isopropyl-carbamic acid tert-butyl ester (from step C above) in N,N-dimethylformamide (7 mL) was added dropwise and stirred at room temperature for 90 minutes. The mixture was poured into ice/water (1500 mL) and extracted with ether (4×250 mL). The ether was dried (Na2SO4) and concentrated in vacuo to give 6.5 g, (95%) isopropyl-[2-(4-isothiocyanato-phenoxy)-ethyl]-carbamic acid tert-butyl ester. Mass spectrum (ES) MH+=367.

Provenance & Evidence