Cyanamide → [4-Amino-2-[4-(2-ethylamino-ethoxy)-phenylamino]-thiazol-5-yl]-(2,3-dihydro-benzofuran-5-yl)-methanone

Participants

Role	Name	HCID	Charge
Reactant	Cyanamide	HCID 9864	—
Reactant	2-Bromo-1-(2,3-dihydro-1-benzofuran-5-yl)ethan-1-one	HCID 10105727	—
Reactant	Ethyl-[2-(4-isothiocyanato-phenoxy)-ethyl]-carbamic acid tert-butyl ester	HCID 23525784	—
Product	[4-Amino-2-[4-(2-ethylamino-ethoxy)-phenylamino]-thiazol-5-yl]-(2,3-dihydro-benzofuran-5-yl)-methanone	HCID 10071007	—

Reaction Steps

This compound was prepared from cyanamide, ethyl-[2-(4-isothiocyanato-phenoxy)-ethyl]-carbamic acid tert-butyl ester of Example 129 and 2-bromo-1-(2,3-dihydro-benzofuran-5-yl)ethanone (from Example 141) following a procedure similar to Example 132. Mass spectrum (ES) MH+=425.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US06818663B2
Source dataset	uspto-grants-2004_11
ORD ID	ord-d53036dfe1bf44709a5d0b4d0c5b6496
Source note	uspto-grants-2004_11