HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(2-(P-NO2Phenoxy)ethyl)imidazole → 4-[2-(1H-Imidazol-1-yl)ethoxy]aniline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(2-(P-NO2Phenoxy)ethyl)imidazole | HCID 13569186 | — |
| Reactant | Ethyl ether methylene chloride | HCID 21881112 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 4-[2-(1H-Imidazol-1-yl)ethoxy]aniline | HCID 13569203 | 75% |
Reaction Steps
Hydrogenation of the nitro compound (Step A above) in ethanol with 10% palladium on carbon at 2 atmospheres pressure gave, after filtration, evaporation, and crystallization from dichloromethane/ether, 75% yield of 4-(2-imidazol-1-yl-ethoxy)-phenylamine as a light orange solid, mp 93-94° C. Mass spectrum (LR-APCI) MH+=203.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06818663B2 |
| Source dataset | uspto-grants-2004_11 |
| ORD ID | ord-d0925e5154324f44adc719014dcd8b02 |
| Source note | uspto-grants-2004_11 |