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Hydrochloric Acid → n-(2-Hydroxy-3phenoxypropyl)-1,1-dimethyl-2-phenylethylamine hydrochloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | N-[2-Hydroxy-3-(4-methoxyphenoxy)propyl]-1,1-dimethyl-2-(4-methoxyphenyl)ethylamine Hydrochloride | HCID 22640899 | — |
| 反応物 | N-(2-Hydroxy-3-isopropoxypropyl)-1,1-dimethyl-2-(4-methoxyphenyl)ethylamine | HCID 22640903 | — |
| 溶媒 | Diethyl Ether | HCID 3283 | — |
| 生成物 | n-(2-Hydroxy-3phenoxypropyl)-1,1-dimethyl-2-phenylethylamine hydrochloride | HCID 22640946 | — |
反応手順
Using the method of Example 5, supra, 1,2-epoxy-3-phenoxypropane (600 mg, 4 mmol) and 1,1-dimethyl-2-phenylethylamine (596 mg, 4 mmol) yielded the title compound: GC/EI-MS, m/z (rel. int.) 284 (M+1, 1), 208 (100), 162 (1), 133 (7), 91 (27), 77 (15), 70 (22). The free base in diethyl ether was treated with excess 1M HCl (diethyl ether). The resulting solid was recrystallized from hot acetonitrile to afford 596 mg of the hydrochloride product as a white solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06818660B2 |
| 出典データセット | uspto-grants-2004_11 |
| ORD ID | ord-356c0254295b427aa3515deba2697e87 |
| 出典メモ | uspto-grants-2004_11 |