Phenyl glycidyl ether → HCID 22640907, compound

HRID 2415339Notes

Reaction equation

HRID 2415339 reaction equation
[CH2:1]([O:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)[CH:2]1[O:4][CH2:3]1.[CH3:12][C:13]([NH2:25])([CH3:24])[CH2:14][C:15]1[CH:20]=[CH:19][C:18]([O:21][CH3:22])=[C:17]([F:23])[CH:16]=1>>[OH:4][CH:2]([CH2:1][O:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)[CH2:3][NH:25][C:13]([CH3:24])([CH3:12])[CH2:14][C:15]1[CH:20]=[CH:19][C:18]([O:21][CH3:22])=[C:17]([F:23])[CH:16]=1

Participants

3

Reactant 2

HCID 31217Phenyl glycidyl etherHCID 53761145HCID 53761145, compound

Product 1

HCID 22640907HCID 22640907, compound

Procedure

Using the method of Example 6, supra, phenyl glycidyl ether (150 mg, 1.1 mmol) and 1,1-dimethyl-2-(3-fluoro-4-methoxyphenyl)ethylamine (197 mg, 1 mmol) were used to prepare the title compound. The title compound crystallized on standing to yield 169 mg of small crystals: GC/EI-MS, m/z (rel. int.) 332 (M+−15, 0.1), 209 (16), 208 (100), 139 (13), 133 (5), 114 (7), 107 (6), 77 (11), 71 (12), 70 (20), 58 (9).

Sources & evidence

ORD record
ord-0f28d73d7bf5486986babe3c90e3bdf1
Source dataset
uspto-grants-2004_11
Patent number
US06818660B2

Reaction notes

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