Dimethylformamide → 6-[(3-Fluorophenyl)methoxy]-3,4-dihydroisoquinolin-1(2H)-one

HRID 2415435ノート

反応式

HRID 2415435 の反応式
[OH:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[C:8](=[O:12])[NH:7][CH2:6][CH2:5]2.[F:13][C:14]1[CH:15]=[C:16]([CH:19]=[CH:20][CH:21]=1)[CH2:17]Br.C(=O)([O-])[O-].[K+].[K+].CN(C)C=O>O>[F:13][C:14]1[CH:15]=[C:16]([CH:19]=[CH:20][CH:21]=1)[CH2:17][O:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[C:8](=[O:12])[NH:7][CH2:6][CH2:5]2

参加物

6

反応物 4

HCID 6228DimethylformamideHCID 11430Potassium CarbonateHCID 680073-Fluorobenzyl bromideHCID 159083146-Hydroxy-1,2,3,4-tetrahydroisoquinolin-1-one

生成物 1

HCID 226419086-[(3-Fluorophenyl)methoxy]-3,4-dihydroisoquinolin-1(2H)-one収率 87.6%

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
90 °C

実験手順

A mixture of 6-hydroxy-3,4-dihydro-2H-isoquinolin-1-one (0.400 g, 2.44 mmol), 3-fluorobenzyl bromide (0.509 g, 2.69 mmol), potassium carbonate (0.372 g, 2.69 mmol) and N,N-dimethylformamide (5 ml) was heated to 90° C. for 8 h. Water was added and the resulting precipitate was washed with diethylether and then dried under high vacuum to afford the title compound (0.580 g, 87%). MS: m/e=272.3 (M+H+).

後処理

  1. washthe resulting precipitate was washed with diethylether
  2. customdried under high vacuum

出典と根拠

ORDレコード
ord-8e90f22ff5294ac0beea682338ca74da
出典データセット
uspto-grants-2004_11
特許番号
US06818774B2

反応ノート

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