Lithium Hydroxide → HCID 22641887, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of the 2-[6-(4-fluoro-benzyloxy)-1-oxo-3,4-dihydro-1H-isoquinolin-2-yl]-2-methyl-propionic acid ethyl ester (220 mg, 0.571 mmol) and lithium hydroxide (274 mg, 11.41 mmol) in water and dioxane (1:1 v:v, 5 mL) was stirred at 50° C. overnight. The dioxane was evaporated and the mixture acidified to pH 3-4 with 0.1 N HCl. After extraction with ethyl acetate, drying of the organic layer with magnesium sulfate, filtration and evaporation a white solid was obtained (196 g, 96%). MS: m/e 356.1 (M−H+).

Provenance & Evidence