HCID 10472529, compound → HCID 22641933, compound

Participants

Reaction Steps

2-[6-(4-Fluoro-benzyloxy)-1-oxo-3,4-dihydro-1H-isoquinolin-2-yl]-propionamide (example 10) (3 g, 8.76 mmol) was solved in dry ethanol (150 mL) and under an argon flow, palladium on charcoal 10% was added (93 mg, 0.0876 mmol). The argon was evacuated and replaced by hydrogen. The reaction mixture was stirred overnight and after evacuation of the hydrogen and replacement by argon the system was opened and the reaction filtrated to remove the palladium and concentrated. After concentration the compound was obtained as a white solid (2.17 g, 100%). MS: m/e=232.8 (M−H+).

Provenance & Evidence