Water → HCID 69034930, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of (5-(4-fluoro-benzyloxy)-2-iodo-phenyl]-acetic acid (example 45a, 355 mg, 0.919 mmol) and 1,1′-carbonyl-diimidazole (164 mg, 1.01 mmol) in N,N′-dimethylformamide (2 mL) was stirred at 50° C. for 1.5 h. H-L-alanine-NH2HCl (145 mg, 1.16 mmol) was added and the mixture was stirred at 50° C. overnight. Water was added and the product precipitated. The solid was filtrated (368 mg, 88%). MS: m/e=457.2 (M+H+).

Provenance & Evidence