Methanol → HCID 69782806, compound

Participants

Reaction Steps

The 4-(4-fluoro-benzyloxy)-2-methoxycarbonylmethyl-benzoic acid (1.15 g, 3.6 mmol) is solved in THF (28 mL) and borane-dimethylsulfide complex is added (0.69 mL, 7.26 mmol) at 0° C. The reaction is stirred for 2 hours at room temperature and more borane-dimethylsulfide complex (0.69 mL, 7.26 mmol) is added at 0° C. The reaction mixture was stirred at room temperature for 7 h. Methanol was added very slowly and the mixture stirred 20 min. Filtration and concentration in a rotatory evaporator left a solid that was purified through a Silica-gel column using hexane/ethyl acetate 3/1 to 1/2 as eluents (0.927 g, 71.4%). MS: m/e=304 (M+).

Provenance & Evidence