反应详情

A solution of 13 g of 7-benzyloxy-2-methyl-4-pyrrolidin-1-yl-quinoline, product of example 1, dissolved in 750 ml of MeOH was treated with 4 g of palladium on charcoal (10%) and then hydrogenated at RT for 1.5 h until HPLC analysis indicated the completion of the reaction. The catalyst was filtered off, washed with water) and the solution was concentrated in vacuo. The solid that precipitated was collected by filtration and dried in a high vacuum to give 8.9 g (96.2%) of 2-methyl-4-pyrrolidin-1-yl-quinolin-7-ol as an amorphous yellow solid. ISP mass spectrum, m/e: 229.2 (M+1 calculated for C14H16N2O: 229).

1. customthe completion of the reaction
2. filtrationThe catalyst was filtered off
3. washwashed with water) and the solution
4. concentrationwas concentrated in vacuo
5. customThe solid that precipitated
6. filtrationwas collected by filtration
7. customdried in a high vacuum