Furan, 2-(bromomethyl)tetrahydro- → HCID 22641297, compound

HRID 2415470Notes

Reaction equation

HRID 2415470 reaction equation
[CH3:1][C:2]1[CH:11]=[C:10]([N:12]2[CH2:16][CH2:15][CH2:14][CH2:13]2)[C:9]2[C:4](=[CH:5][C:6]([OH:17])=[CH:7][CH:8]=2)[N:3]=1.[CH2:18](Br)[CH:19]1[O:23][CH2:22][CH2:21][CH2:20]1>>[CH3:1][C:2]1[CH:11]=[C:10]([N:12]2[CH2:16][CH2:15][CH2:14][CH2:13]2)[C:9]2[C:4](=[CH:5][C:6]([O:17][CH2:18][CH:19]3[CH2:20][CH2:21][CH2:22][O:23]3)=[CH:7][CH:8]=2)[N:3]=1

Participants

3

Reactant 2

HCID 14501Furan, 2-(bromomethyl)tetrahydro-HCID 1358041182-Methyl-4-pyrrolidin-1-yl-quinolin-7-ol

Product 1

HCID 22641297HCID 22641297, compound

Procedure

In analogy to example 6 there was prepared: on reaction of 2-methyl-4-pyrrolidin-1-yl-quinolin-7-ol with tetrahydro-furfuryl bromide, whereby the product was isolated as free base, (rac) 2-methyl-4-pyrrolidin-1-yl-7-(tetrahydro-furan-2-ylmethoxy)-quinoline as a yellow-brown waxy solid. ISP mass spectrum, m/e: 313.2 (M+1 calculated for C19H24N2O2: 313).

Workup

  1. customIn analogy to example 6 there was prepared

Sources & evidence

ORD record
ord-dd89fcd236cd438885add27179453cc7
Source dataset
uspto-grants-2004_11
Patent number
US06818767B2

Reaction notes

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