Pyrrolidine → HCID 22641362, compound

Participants

Reaction Steps

A solution of 1 g (3.07 mmol) of 7-benzyloxy-6-butyl-4-chloro-quinoline hydrochloride in 2.5 ml (30.7 mmol) of pyrrolidine was heated at 60° C. with stirring under an argon atmosphere for 24 h after which time the reaction was completed according to HPLC analysis. The excess pyrrolidine was evaporated off, and the residue was partitioned between EtOAc and water. The layers were separated and the aqueous layer once extracted with AcOEt. The combined organic layers were washed with water then saturated NaCl solution, dried over magnesium sulphate and concentrated in vacuo to give 1.12 g (97.4%) of the 7-benzyloxy-6-butyl-4-pyrrolidin-1-yl-quinoline as a brown oil. ISP mass spectrum, m/e: 361.3 (M+1 calculated for C24H28N2O: 361).

Provenance & Evidence