Benzoic acid, 4-(bromomethyl)-2-ethoxy-, ethyl ester → Ethyl 2-ethoxy-4-(2-ethoxy-2-oxoethyl)benzoate

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Reaction Steps

A mixture ethyl 4-bromomethyl-2-ethoxy-benzoate (4, 1 gm, 3.5 mmol), dichlorobis-(triphenylphosphine)palladium catalyst (0.1 gm), ethyl alcohol (5 ml) was heated to 50° C. with CO for 6-15 hrs. Catalyst was filtered and solvent was removed to yield the product ethyl 3-ethoxy-4-ethoxycarbonyl-phenylacetate (1, 0.75 gm, 2.6 mmol, 76%).

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