反应详情

2-(Trifluoromethyl)-[1,2,4]triazolo[1,5-a]pyrazine (340 mg, 1.81 mmol, from Step C) was hydrogenated under atmospheric hydrogen with 10% palladium on carbon (60 mg) as a catalyst in ethanol (10 mL) at ambient temperature for 18 h. Filtration through Celite followed by concentration gave a dark colored oil. Flash chromatography (eluted with 100% ethyl acetate followed by 10% methanol/dichloromethane) gave the title compound as a white solid.

1. filtrationFiltration through Celite
2. concentrationfollowed by concentration
3. customgave a dark colored oil
4. washFlash chromatography (eluted with 100% ethyl acetate followed by 10% methanol/dichloromethane)