Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 4-Chloro-2,8-bis(trifluoromethyl)quinoline | HCID 2733247 | — |
| Reactant | N-(7-chloroquinolin-4-yl)cyclohexane-1,4-diamine | HCID 18391686 | — |
| Solvent | 1-Methylpyrrolidine | HCID 8454 | — |
| Product | HCID 178506235 | HCID 178506235 | — |
Reaction Steps
A solution of N-(7-chloroquinolin-4-yl)-cyclohexane-1,4-diamine (20 mg, 0.07 mmol) in N-methylpyrrolidine (0.5 mL) at 150° C. was treated with 4-chloro-2,8-bis(trifluoromethyl)quinoline (21 mg, 0.07 mmol), and triethylamine (10 μl, 0.07 mmol). The mixture was stirred at 150° C. for 18 hours then concentrated under reduced pressure. The compound was purified by reverse phase HPLC to provide the desired compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06818772B2 |
|---|
| Source dataset | uspto-grants-2004_11 |
|---|
| ORD ID | ord-83fe841798394d9599d6c5f1a73d166f |
|---|
| Source note | uspto-grants-2004_11 |
|---|
