1-Bromo-3,5-difluorobenzene → HCID 178505933, compound

Participants

Reaction Steps

A mixture of example 23A (30 mg, 0.11 mmol), 1-bromo-3,5-difluorobenzene (25 mg, 0.132 mmol), Pd2(dba)3 (1 mg, 0.001 mmol), 2,2′-bis(diphenylphosphino)-1,1′-binaphtyl (1.6 mg, 002 mmol) and sodium-tert-btoxide (14 mg, 0.132 mmol) was heated for 15 hours in ethyleneglycoldimethylether, concentrated and the residue was purified with high throughput HPLC system to provide the desired compound as its bis trifluoroacetic acid salt. MS (ESI(+)Q1MS m/z 388 (M+H)+); 1H NMR (300 MHz, DMSO-D6) δ ppm 8.91 (d, 1 H), 8.71 (d, 1 H), 8.55 (d, 1 H), 7.92 (d, 1 H), 7.80 (dd, 1 H), 7.01 (d, 1 H), 6.25 (m, 4 H), 3.86-4.10 (br.s, 1 H), 3.54 (br.s, 1 H), 3.54 (m, 8 H).

Provenance & Evidence