N-Benzylglycine ethyl ester → 2-(Benzylamino)acetic acid

Participants

Reaction Steps

N-benzylglycine ethyl ester (97.0 g, 503 mmol) was refluxed in 260 mL of water (with 480 mg of KOH, 0.5 wt %) overnight. The reaction mixture was filtered. The filtercake was washed with chloroform and dried under vacuum. The filtrate was extracted with tert-butyl methyl ether. The aqueous phase from this extraction was separated, adjusted to pH 2 with 6M HCl, and then concentrated in vacuo. The residue was filtered and this filtercake was washed with chloroform and dried under vacuum. The two filtercakes were combined.

Provenance & Evidence