2-(Benzylamino)acetic acid → Ethyl 1-benzylhexahydropyrrolo[3,4-b]pyrrole-5(1H)-carboxylate

Participants

Reaction Steps

To a two-liter round bottom flask was added 81.5 g (476 mmol) of ethyl N-allyl-N-(2-oxoethyl)-carbamate (I-3c), 78.6 g (476 mmol) of N-benzylglycine (I-3d), and 1.2 liters of toluene. The reaction mixture was refluxed for 24 hours. The reaction mixture was then decanted to remove sludge residue which formed on the bottom of the flask. The decanted solution was concentrated in vacuo to a brown syrup.

Provenance & Evidence